the safety of iron dextran and a comparison with iron sucrose

the safety of iron dextran and a comparison with iron sucrose

THE SAFETY OF IRON DEXTRAN AND A COMPARISON

THE SAFETY OF IRON DEXTRAN AND A COMPARISON WITH IRON SUCROSE FOR INTRAVENOUS USE: A SHORT REPORT TO THE WORLD HEALTH ORGANIZATION ADVISORY COMMITTEE ON THE SAFETY OF MEDICINES. From: Peter I Folb Date: 18th October 2004 Background 1. At a meeting of the WHO Expert Committee on the Use of

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The Comparative Safety of Intravenous Iron Dextran, Iron ...

The efficacy and safety of parenteral iron sucrose use have been demonstrated in several clinical studies and have been confirmed by extensive clinical practice [43]. To supply the quantities ...

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A Head-to-Head Comparison of the Safety and Efficacy of ...

2010-11-19 · Iron sucrose is approved in many countries outside the US for the treatment of IDA in patients intolerant to oral iron therapy, and is considered a safer alternative to IV iron dextran. This open-label trial (n=600) will evaluate the efficacy and safety of a 1.02 g of IV ferumoxytol, administered as 2 doses of 510 mg each, compared with 1.0 g ...

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Low-molecular weight iron dextran and iron sucrose have ...

2008-3-1 · Low-molecular weight iron dextran has been administered without anaphylaxis as an intravenous push of up to 200 mg over 2 minutes or as a total-dose infusion of doses up to 3,000 mg over 4 hours. 6 Nonetheless, a test dose is still recommended, although the value of the test dose has never been validated in any study. In an economic analysis of the total-dose infusion

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Iron Dextran Versus Iron Sucrose for Non-Hemodialysis ...

2011-11-18 · Intravenous (IV) iron is an alternative treatment for patients intolerant or non-responsive to oral formulations. Of the two most common formulations available in Canada, IV iron dextran is less expensive but may be associated with

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Safety of intravenous iron formulations: facts and folklore

2014-4-9 · Safety issues with intravenous iron. By 1990, the use of IV iron in dialysis centres had escalated rapidly. Imferon ® was the formulation most used. Although serious adverse events occurred infrequently, the nephrology community rapidly adopted the addition of IV iron to the treatment paradigm of dialysis-associated anaemia with observed improvements in

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Direct Comparison of the Safety and Efficacy of Ferric ...

Several intravenous iron complexes are available for the treatment of iron deficiency anemia (IDA). Iron dextran (DEX) is associated with an elevated risk of potentially serious anaphylactic reactions, whereas others must be administered in several small infusions to avoid labile iron reactions. Ferric carboxymaltose (FCM) is a nondextran intravenous iron which can be

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Clinical Study Direct Comparison of the Safety and ...

2019-7-31 · Direct Comparison of the Safety and Efficacy of Ferric Carboxymaltose versus Iron Dextran in Patients with Iron Deficiency Anemia IftikharHussain, 1 JessicaBhoyroo, 1 AngeliaButcher, 2 ToddA.Koch, 2 AndyHe, 2 andDavidB.Bregman 2,3 Vital Prospects Clinical Research Institute, PC, Tulsa, OK, USA Luitpold Pharmaceuticals, Inc., Norristown, PA , USA

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Safety and effectiveness of intravenous iron sucrose ...

We did a multicentre, open-label, phase 3, randomised, controlled trial at four government medical colleges in India. Pregnant women, aged 18 years or older,

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FERAHEME® vs Venofer® | Comparative efficacy & safety

A randomized, open-label, multicenter clinical trial of 162 patients with IDA and CKD compared the efficacy and safety of FERAHEME vs iron sucrose. FERAHEME was administered as two 510-mg injections (prior method of administration that

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A Head-to-Head Comparison of the Safety and Efficacy of ...

2010-11-19 · Iron sucrose is approved in many countries outside the US for the treatment of IDA in patients intolerant to oral iron therapy, and is considered a safer alternative to IV iron dextran. This open-label trial (n=600) will evaluate the efficacy and safety of a 1.02 g of IV ferumoxytol, administered as 2 doses of 510 mg each, compared with 1.0 g ...

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Randomized double-blind safety comparison of

2016-3-11 · Randomized double-blind safety comparison of intravenous iron dextran versus iron sucrose in an adult non-hemodialysis outpatient population: A feasibility study. Martha L Louzada Department of Medicine, Division of Hematology, London, ON Canada ; University of Western Ontario, London, ON Canada.

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Low-molecular weight iron dextran and iron sucrose have ...

2008-3-1 · Low-molecular weight iron dextran has been administered without anaphylaxis as an intravenous push of up to 200 mg over 2 minutes or as a total-dose infusion of doses up to 3,000 mg over 4 hours. 6 Nonetheless, a test dose is still recommended, although the value of the test dose has never been validated in any study. In an economic analysis of the total-dose infusion

Read More
Clinical Study Direct Comparison of the Safety and ...

2019-7-31 · Direct Comparison of the Safety and Efficacy of Ferric Carboxymaltose versus Iron Dextran in Patients with Iron Deficiency Anemia IftikharHussain, 1 JessicaBhoyroo, 1 AngeliaButcher, 2 ToddA.Koch, 2 AndyHe, 2 andDavidB.Bregman 2,3 Vital Prospects Clinical Research Institute, PC, Tulsa, OK, USA Luitpold Pharmaceuticals, Inc., Norristown, PA , USA

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Efficacy and safety of iron isomaltoside (Monofer®) in the ...

2016-3-10 · It has been suggested that parenteral iron may have a direct toxic effect on renal tubular cells. Zager et al33 compared the nephrotoxicity of iron sucrose, iron gluconate, iron dextran, and iron isomaltoside over a broad dosage range (control and range: 30–1,000 μg iron/mL). In vitro toxicity was assessed by reduction in tubule adenosine ...

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Comparison of ferric Carboxymaltose and iron sucrose ...

2019-2-4 · To evaluate the efficacy and safety of intravenous Ferric Carboxymaltose. (FCM) in comparison with intravenous Iron sucrose complex (ISC) for treatment of iron deficiency anemia in pregnancy.A randomized clinical trial was conducted from (January 2016–August ...

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Safety and effectiveness of intravenous iron sucrose ...

We did a multicentre, open-label, phase 3, randomised, controlled trial at four government medical colleges in India. Pregnant women, aged 18 years or older, at 20–28 weeks of gestation with a haemoglobin concentration of 5–8 g/dL, or at

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A comparative study of efficacy, safety and compliance of ...

Myers B et al.18 conducted a retrospective analysis of pregnant women treated with ferric carboxymaltose and iron dextran. Of the 92 women, 44 received i.v FCM and 48 received i.v Iron Dextran . At two weeks, the mean Hb rise in the FCM group was 1.73 g/dL and 1.34 g/dL in the Iron Dextran group.

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The safety of intravenous iron dextran in hemodialysis ...

1996-10-1 · The purpose of this study was to evaluate the safety of this medication. Charts from four hemodialysis centers of all 573 patients treated with intravenous iron dextran (INFeD; Schein Pharmaceutical, Inc, Florham Park, NJ) between July 1, 1993, and June 30, 1995, were studied.

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Safety and efficacy of rapid (1,000 mg in 1 hr ...

2016-3-11 · The IV formulations available for use in pregnancy include iron sucrose, ferric gluconate, LMW iron dextran, and ferric carboxymaltose (FCM). Their safety and efficacy are similar 16, 30, 31. Iron sucrose and ferric gluconate require multiple visits since doses exceeding 200 mg are associated with frequent unpleasant infusion reactions 32. In ...

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Comparison of adverse-event profiles of intravenous low ...

2011-1-1 · Comparison of adverse-event profiles of intravenous low-molecular-weight iron dextran and iron sucrose in peritoneal dialysis patients. Yalcin Solak. Department of Nephrology, Meram School of Medicine, Selcuk University, Meram, Konya, Turkey. [email protected]

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Safety and efficacy of intravenous iron polymaltose, iron ...

2017-9-18 · Introduction. Iron deficiency represents the most widespread nutritional deficiency globally and is the leading cause of anaemia during pregnancy. 1 Anaemia is estimated to affect almost 40% of pregnancies worldwide and is associated with a significantly increased risk of perinatal morbidity and mortality, 1, 2 including risk of low birth weight and preterm birth. 3

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Payment Incentives and the Use of Higher-Cost Drugs: A ...

2020-12-9 · Auerbach M, Al Talib K. Low-molecular weight iron dextran and iron sucrose have similar comparative safety profiles in chronic kidney disease. Kidney Int . 2008;73(5):528-530. doi:10.1038/sj.ki ...

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Safety and Efficacy of Intravenous Iron Sucrose versus Low ...

Practitioner T. Intravenous iron sucrose (Venofer). 2008:1–11. 12. Practitioner T Protocol for the use of intravenous iron dextran (CosmoFer ®). 2008:1–11. 13. Sinha S, Chiu DYY, Peebles G, et al. Comparison of intravenous iron sucrose versus low-molecular-weight iron dextran in chronic kidney disease.

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Intravenous iron sucrose v/s oral ferrous fumarate for ...

2017-5-8 · The objective of this study was to compare the efficacy, safety and tolerability of intravenous iron sucrose with that of oral ferrous fumarate in iron deficiency anemia during 14 to 34 weeks of pregnancy. A randomized controlled trial was performed involving 112 patients attending the antenatal clinic at Shri B.M.Patil Medical college Hospital, Bijapur from October

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Clinical Use of Intravenous Iron: Administration, Efficacy ...

2010-12-4 · Iron has been used to treat anemia for more than 300 years. In Stockman's 1893 review of the treatment of chlorosis, he attributes the first use of oral iron to Sydenham in 1681. 1 It was not until the 19 th century when Pierre Blaud 2 introduced ferrous sulfate and reported cures of chlorosis that oral iron therapy became standard care for what is now recognized as

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Adverse events associated with intravenous iron infusion ...

2007-4-20 · Iron dextran: 5/34 (14.7% of patients, 7.4% of injections) had ADE, mostly minor (unclear what form of iron dextran) Iron saccharate: 2/23 (8.7% of patients, 4.3% of injections) had minor ADEs: No deaths, hospitalizations or permanent disabilities. ADEs were similar for both groups. 3. Iron dextran compared with iron gluconate: Chertow et al ...

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The Pharmacokinetics and Pharmacodynamics of Iron

2011-1-4 · 1. Introduction. Iron is an essential component of every cell in the body. Although best known for its critical role in the transport and storage of oxygen (in hemoglobin and myoglobin, respectively), within a large variety of enzymes iron also acts as a carrier for electrons, a catalyst for oxygenation, hydroxylation, and is necessary for cellular growth and proliferation.

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FERAHEME® vs Venofer® | Comparative efficacy & safety

A randomized, open-label, multicenter clinical trial of 162 patients with IDA and CKD compared the efficacy and safety of FERAHEME vs iron sucrose. FERAHEME was administered as two 510-mg injections (prior method of administration that

Read More
A comparative study of efficacy, safety and compliance of ...

Myers B et al.18 conducted a retrospective analysis of pregnant women treated with ferric carboxymaltose and iron dextran. Of the 92 women, 44 received i.v FCM and 48 received i.v Iron Dextran . At two weeks, the mean Hb rise in the FCM group was 1.73 g/dL and 1.34 g/dL in the Iron Dextran group.

Read More